Exactness and Approximation of the Stochastic Simulation Algorithm

Mura, Ivan (2008) Exactness and Approximation of the Stochastic Simulation Algorithm. UNSPECIFIED. (Unpublished)

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    Abstract

    This short note intends to clarify about the applicability of the Stochastic Simulation Algorithm proposed by Gillespie for the analysis of systems of coupled biochemical reactions. The derivation of Gillespie’s results is revisited to pinpoint those steps at which, depending on the validity of the assumptions adopted about the system to be studied, approximations may be introduced. We discuss about the ways the inaccuracies entailed by the approximations may propagate and affect simulation results.

    Item Type: Departmental Technical Report
    Department or Research center: CoSBi (Center for Computational and Systems Biology)
    Subjects: Q Science > QA Mathematics > QA076 Computer software > QA076.7 Programming Languages - Semantics
    Report Number: TR-12-2008
    Repository staff approval on: 01 Dec 2009

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